LL-37 5mg

LL-37 Peptide

Quick Overview (TL;DR)
LL-37 is an experimental peptide that scientists are studying because it helps the body fight bacteria, viruses, and inflammation. It’s naturally made in humans and seems to support wound healing and infection control. This peptide isn’t approved for medical treatments yet, but early research suggests it could be useful for healing wounds faster and boosting the immune system.

Detailed Scientific Description
What is LL-37?
LL-37 is an experimental cationic host defense peptide derived from the human cathelicidin antimicrobial protein called hCAP-18. Researchers are exploring it for its broad-spectrum antimicrobial, antiviral, and immunomodulatory properties. It plays a vital role in the body’s innate immune system, helping protect against pathogens and supporting tissue repair.

How It Works (Mechanism of Action)
LL-37 works through multiple pathways:

• Direct Antimicrobial Activity
• Binds to the membranes of microbes, causing them to break apart and die.
• Neutralizes bacterial toxins like lipopolysaccharides (LPS).
• Immunomodulation
• Regulates the release of cytokines, balancing inflammation.
• Helps recruit immune cells (neutrophils, monocytes, T-cells) to the site of infection.
• Tissue Repair and Wound Healing
• Stimulates new blood vessel formation and helps skin cells regrow.
• Promotes cell movement and proliferation to close wounds.
• Potential Benefits & Research Applications
• Broad-Spectrum Antimicrobial Action: Active against bacteria, viruses, and fungi, including some antibiotic-resistant strains.
• Wound Healing Support: May speed up chronic wound closure and tissue regeneration.
• Anti-Inflammatory Properties: Helps calm excessive inflammation.
• Immune Enhancement: Strengthens innate immune defenses on the skin and mucous membranes.
• Potential Antiviral Effects: Early studies suggest activity against influenza, HIV, and other viruses.

Typical Dosage & Administration

Administration: Experimental use as a topical cream or subcutaneous injection.

• Dosage: No standardized dosing protocols exist; research studies typically use concentrations ranging from 100–500 micrograms per application, depending on the formulation and purpose.

Possible Side Effects

• Local Irritation: Redness, swelling, or discomfort at the site of application.
• Allergic Reactions: Rash or hypersensitivity in some individuals.
• Potential Cytotoxicity: High doses may be harmful to human cells in lab studies.

LL-37 is only available for research use and is not approved for medical treatments.

Under investigation for wound care, infection control, and immune modulation.

Typically stored in a freeze-dried (lyophilized) form at -20°C, and reconstituted before use.