SS-31 50mg

SS-31 (Elamipretide)

What is SS-31?

SS-31, also known as Elamipretide, is a mitochondria-targeting peptide developed to improve mitochondrial function, reduce oxidative stress, and protect against cellular damage. It is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) that selectively accumulates in the inner mitochondrial membrane, where it stabilizes cardiolipin, a phospholipid critical for mitochondrial structure and function.

SS-31 is being researched for its potential to treat mitochondrial diseases, cardiovascular conditions, age-related decline, and neurodegenerative disorders. It is recognized for its ability to restore mitochondrial efficiency and protect cells from energy failure.

How It Works (Mechanism of Action)

SS-31 functions at the mitochondrial level by binding to cardiolipin, which stabilizes mitochondrial membranes and enhances electron transport efficiency in the respiratory chain.

Targets Mitochondria Directly

• Selectively accumulates in the inner mitochondrial membrane without the need for a transporter.

• Preserves mitochondrial membrane integrity and prevents dysfunction.

Stabilizes Cardiolipin

• Prevents oxidation and degradation of cardiolipin, which is essential for electron transport and ATP synthesis.

• Supports optimal function of the electron transport chain (ETC).

Reduces Oxidative Stress

• Decreases production of reactive oxygen species (ROS) and mitochondrial-derived free radicals.

• Protects cells from apoptosis and inflammatory damage.

Improves ATP Production

• Enhances cellular energy output, especially in metabolically active tissues like the heart, brain, muscles, and kidneys.

Potential Benefits & Use Cases

• Mitochondrial Dysfunction Support: Therapeutic candidate for mitochondrial myopathies and degenerative diseases.

• Cardioprotection: Shown to improve heart function in models of heart failure, ischemia, and reperfusion injury.

• Neuroprotection: May slow or reverse neurodegenerative processes in diseases such as Alzheimer’s and Parkinson’s.

• Kidney Health: Demonstrated renoprotective effects in acute and chronic kidney injury.

• Anti-Aging & Longevity: Helps combat age-related mitochondrial decline and supports cellular resilience.

• Muscle Endurance & Recovery: Improves muscle performance, especially in conditions of fatigue or mitochondrial weakness.

Typical Dosage & Administration

• Administration: Subcutaneous or intravenous injection (depending on formulation and use case).

• Dosage:

  • 2 mg – 10 mg per day, typically administered once daily subcutaneously.

  • Dosing varies depending on the condition being addressed and ongoing clinical trial protocols.

Possible Side Effects

SS-31 has shown an excellent safety profile in both animal and human studies. Reported side effects are rare and typically mild:

• Injection site irritation (redness, swelling, or discomfort).

• Occasional mild headache or nausea.

• No known toxic effects at therapeutic doses.

Other Relevant Details

• SS-31 is not a growth hormone secretagogue or an anabolic peptide; its effects are restorative and mitochondria-specific.

• Often researched in combination with interventions aimed at improving metabolic health, such as NAD+ precursors or exercise mimetics.

• Being evaluated in clinical trials for mitochondrial diseases (e.g., Barth syndrome), heart failure, and age-related muscle dysfunction.